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Article

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.

Scientific reports - 21 Nov 2017

Mori Raffaele, Wauman Joris, Icardi Laura, Van der Heyden José, De Cauwer Lode, Peelman Frank, De Bosscher Karolien, Tavernier Jan

Abstract excerpt

STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects. Of the STAT-mediated signal transduction pathways, STAT3 transcriptional control is best understood. Jak kinase dependent activation of STAT3 relies on Y705 phosphorylation triggering a conformational...

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Source

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Identifiers

PMID: 29162862
DOI: 10.1038/s41598-017-15912-6
PMCID: PMC5698428

Genes

STAT3
LIF
TYK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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