Article
CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese.
Journal of neuroimmunology - 1 Feb 2005
Fukazawa Toshiyuki, Kikuchi Seiji, Miyagishi Ryuji, Niino Masaaki, Yabe Ichiro, Hamada Takeshi, Sasaki Hidenao
Abstract excerpt
We investigated the polymorphisms of exon 1 (+49A/G) and promoter (-318C/T and -651C/T) regions of the CTLA-4 gene in 133 Japanese patients with conventional/classical multiple sclerosis (MS) and 156 healthy controls. Patients with optico-spinal MS (OSMS) or atypical clinical attacks were excluded from the study. There was no significant difference in the distribution of polymorphisms between patients and...
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