A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese.

doi:10.1177/1352458513482512

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Article

A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 2013

Huang Jian, Yoshimura Satoshi, Isobe Noriko, Matsushita Takuya, Yonekawa Tomomi, Sato Shinya, Yamasaki Ryo, Kira Jun-ichi

Abstract excerpt

BACKGROUND: The G allele of NOTCH4 rs422951 is protective against demyelinating disease in Japanese. OBJECTIVES: The purpose of this study was to assess the relation of the G allele to neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) and multiple sclerosis (MS) and the interaction between the G allele and HLA-DRB1 alleles, and to clarify any association of the G allele with clinical features. METHODS: DNA...

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PMID: 23549433
DOI: 10.1177/1352458513482512

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NOTCH4

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