Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CTLA-4 gene polymorphism may modulate disease in Japanese multiple sclerosis patients.

Journal of the neurological sciences - 1 Dec 1999

Fukazawa T, Yanagawa T, Kikuchi S, Yabe I, Sasaki H, Hamada T, Miyasaka K, Gomi K, Tashiro K

Abstract excerpt

Multiple sclerosis (MS) is widely believed to have a T-cell-mediated autoimmune etiology. The CTLA-4 gene is a strong candidate for involvement in autoimmune diseases because it plays an important role in the termination of T-cell activation. To examine the genetic association of the CTLA-4 gene locus with MS, we analyzed the CTLA-4 gene exon 1 A/G polymorphism in 74 Japanese MS patients and 93 controls. We also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abatacept
Share to Antigens, CD
Share to Antigens, Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Histocompatibility Testing

Share to Immunoconjugates

Share to Immunoglobulins

Share to Multiple Sclerosis

Source

Identifiers

PMID: 10567049
DOI: 10.1016/s0022-510x(99)00251-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CTLA-4 gene polymorphism may modulate disease in Japanese multiple sclerosis patients.PMID 10567049Read ↗

CTLA-4 gene and the susceptibility of multiple sclerosis: an updated meta-analysis study including 12,916 cases and 15,455 controls.Semantic proximity Read ↗

The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.Semantic proximity Read ↗

CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese.Semantic proximity Read ↗

Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis.Semantic proximity Read ↗

CTLA-4 gene polymorphisms (-318C/T, +49A/G, +6230A/G) in Iranian patients with multiple sclerosis.Semantic proximity Read ↗

Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.Semantic proximity Read ↗

CTLA4 dimorphisms and the multiple sclerosis phenotype.Semantic proximity Read ↗

The CTLA-4 gene is associated with multiple sclerosis.Semantic proximity Read ↗

CTLA-4 gene polymorphism in Japanese patients with rheumatoid arthritis.Semantic proximity Read ↗

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study.Semantic proximity Read ↗

Ctla4 and multiple sclerosis in the Italian population.Semantic proximity Read ↗

Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.