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Article

VP40 octamers are essential for Ebola virus replication.

Journal of virology - 1 Feb 2005

Hoenen Thomas, Volchkov Viktor, Kolesnikova Larissa, Mittler Eva, Timmins Joanna, Ottmann Michelle, Reynard Olivier, Becker Stephan, Weissenhorn Winfried

Abstract excerpt

Matrix protein VP40 of Ebola virus is essential for virus assembly and budding. Monomeric VP40 can oligomerize in vitro into RNA binding octamers, and the crystal structure of octameric VP40 has revealed that residues Phe125 and Arg134 are the most important residues for the coordination of a short single-stranded RNA. Here we show that full-length wild-type VP40 octamers bind RNA upon HEK 293 cell expression....

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Source

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Identifiers

PMID: 15650213
DOI: 10.1128/JVI.79.3.1898-1905.2005
PMCID: PMC544139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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