Article
A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress.
Viruses - 17 Oct 2014
Adu-Gyamfi Emmanuel, Soni Smita P, Jee Clara S, Digman Michelle A, Gratton Enrico, Stahelin Robert V
Abstract excerpt
Ebola virus (EBOV) causes viral hemorrhagic fever in humans and can have clinical fatality rates of ~60%. The EBOV genome consists of negative sense RNA that encodes seven proteins including viral protein 40 (VP40). VP40 is the major Ebola virus matrix protein and regulates assembly and egress of...
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