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Article

Ebola Virus Matrix Protein VP40 Single Mutations G198R and G201R Significantly Enhance Plasma Membrane Localization.

The journal of physical chemistry. B - 21 Nov 2024

Cioffi Michael D, Sharma Tej, Motsa Balindile B, Bhattarai Nisha, Gerstman Bernard S, Stahelin Robert V, Chapagain Prem P

Abstract excerpt

Viral proteins frequently undergo single or multiple amino acid mutations during replication, which can significantly alter their functionality. The Ebola virus matrix protein VP40 is multifunctional but primarily responsible for creating the viral envelope by binding to the inner leaflet of the host cell plasma membrane (PM). Changes to the VP40 surface cationic charge via mutations can influence PM...

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Identifiers

PMID: 39326870
DOI: 10.1021/acs.jpcb.4c02700
PMCID: PMC11586905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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