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Article

Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions.

The Journal of biological chemistry - 1 Sept 2025

Motsa Balindile B, Bhowal Barsha, Narkhede Yogesh B, Karki Ukesh, Ramirez Valentina Toro, Eger Samuel W, Wiest Olaf, Chapagain Prem P, Stahelin Robert V

Abstract excerpt

The Ebola virus (EBOV) has been responsible for several outbreaks in Africa over the last decade causing severe hemorrhagic fever with limited treatment options. EBOV is a lipid-enveloped filamentous negative-sense RNA virus with a genome encoding seven proteins. This includes the matrix protein VP40, which regulates assembly and budding of new virions from the inner leaflet of the host cell plasma membrane (PM)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40680839
DOI: 10.1016/j.jbc.2025.110489
PMCID: PMC12409429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions.PMID 40680839Read ↗

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Mutation of Ebola Virus Matrix Protein Cysteine Residues Increases Binding to Phosphatidylserine through Increased Flexibility of a Lipid Binding LoopSemantic proximity Read ↗

Interaction of monomeric Ebola VP40 protein with a plasma membrane: A coarse-grained molecular dynamics (CGMD) simulation study.Semantic proximity Read ↗

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Subcellular Characterization of the Molecular Determinants of Ebola VP40 Trafficking and AssemblySemantic proximity Read ↗

VP40 octamers are essential for Ebola virus replication.Semantic proximity Read ↗

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