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Article

A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.

The Journal of biological chemistry - 2 Mar 2018

Del Vecchio Kathryn, Frick Cary T, Gc Jeevan B, Oda Shun-Ichiro, Gerstman Bernard S, Saphire Erica Ollmann, Chapagain Prem P, Stahelin Robert V

Abstract excerpt

Ebola virus (EBOV) is a filamentous lipid-enveloped virus that causes hemorrhagic fever with a high fatality rate. Viral protein 40 (VP40) is the major EBOV matrix protein and regulates viral budding from the plasma membrane. VP40 is a transformer/morpheein that can structurally rearrange its native homodimer into either a hexameric filament that facilitates viral budding or an RNA-binding octameric ring that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29348171
DOI: 10.1074/jbc.M117.816280
PMCID: PMC5836117

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A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.PMID 29348171Read ↗

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