Article
Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop.
Viruses - 15 Jul 2021
Johnson Kristen A, Bhattarai Nisha, Budicini Melissa R, LaBonia Carolyn M, Baker Sarah Catherine B, Gerstman Bernard S, Chapagain Prem P, Stahelin Robert V
Abstract excerpt
Ebolavirus (EBOV) is a negative-sense RNA virus that causes severe hemorrhagic fever in humans. The matrix protein VP40 facilitates viral budding by binding to lipids in the host cell plasma membrane and driving the formation of filamentous, pleomorphic virus particles. The C-terminal domain of VP40 contains two highly-conserved cysteine residues at positions 311 and 314, but their role in the viral life cycle is...
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