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Article

Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging.

Scientific reports - 9 Aug 2017

Banadyga Logan, Hoenen Thomas, Ambroggio Xavier, Dunham Eric, Groseth Allison, Ebihara Hideki

Abstract excerpt

Ebola virus causes devastating hemorrhagic fever outbreaks for which no approved therapeutic exists. The viral nucleocapsid, which is minimally composed of the proteins NP, VP35, and VP24, represents an attractive target for drug development; however, the molecular determinants that govern the interactions and functions of these three proteins are still unknown. Through a series of mutational analyses, in...

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Share to Ebolavirus
Share to Genome, Viral
Share to Hemorrhagic Fever, Ebola

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28794491
DOI: 10.1038/s41598-017-08167-8
PMCID: PMC5550494

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