Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.

Developmental biology - 1 Feb 2005

Aiyer Aparna R, Honarpour Narimon, Herz Joachim, Srivastava Deepak

Abstract excerpt

HAND2 is an essential transcription factor for cardiac, pharyngeal arch, and limb development. Apoptosis in the HAND2-null embryo causes hypoplasia of the right ventricle and pharyngeal arches leading to lethality by embryonic day (E)10.0 from heart failure. In order to investigate the role of apoptosis in inducing the HAND2-null phenotype, we generated mouse embryos lacking both HAND2 and Apaf-1, a central...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta, Thoracic
Share to Apoptotic Protease-Activating Factor 1
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Branchial Region

Share to Fetal Development

Share to Heart Defects, Congenital

Share to Heart Ventricles

Share to Mesoderm

Source

Identifiers

PMID: 15649468
DOI: 10.1016/j.ydbio.2004.11.001

Genes

HAND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.PMID 15649468Read ↗

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.Semantic proximity Read ↗

Hand2 function in second heart field progenitors is essential for cardiogenesis.Semantic proximity Read ↗

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis.Semantic proximity Read ↗

Apoptosis as an instrument in cardiovascular developmentSemantic proximity Read ↗

Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control.Semantic proximity Read ↗

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function.Semantic proximity Read ↗

NORMAL AND ABNORMAL CONSEQUENCES OF APOPTOSIS IN THE HUMAN HEARTSemantic proximity Read ↗

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.Semantic proximity Read ↗

Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials.Semantic proximity Read ↗

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.Semantic proximity Read ↗

Programmed cell death in the developing heart: Regulation by BMP4 and FGF2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.