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Article

Lsh controls silencing of the imprinted <i>Cdkn1c</i> gene

13 Jan 2005

Abstract excerpt

Epigenetic regulation, such as DNA methylation plays an important role in the control of imprinting. Lsh, a member of the SNF2 family of chromatin remodeling proteins, controls DNA methylation in mice. To investigate whether Lsh affects imprinting, we examined CpG methylation and allelic expression of individual genes in Lsh-deficient embryos. We report here that loss of Lsh specifically alters expression of the...

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PMID: 15647320
DOI: 10.1242/dev.01612

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Lsh controls silencing of the imprinted <i>Cdkn1c</i> genePMID 15647320Read ↗

Silencing of <i>CDKN1C</i> (<i>p57<sup>KIP2</sup> </i>) is associated with hypomethylation at KvDMR1 in Beckwith–Wiedemann syndromeSemantic proximity Read ↗

Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.Semantic proximity Read ↗

Lsh, a member of the SNF2 family, is required for genome-wide methylation.Semantic proximity Read ↗

Methylation at mouse Cdkn1c is acquired during postimplantation development and functions to maintain imprinted expression.Semantic proximity Read ↗

Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation.Semantic proximity Read ↗

The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.Semantic proximity Read ↗

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene ClusterSemantic proximity Read ↗

ZFP57 dictates allelic expression switch of target imprinted genes.Semantic proximity Read ↗

Autonomous silencing of the imprinted Cdkn1c gene in stem cells.Semantic proximity Read ↗

A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.Semantic proximity Read ↗

Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.Semantic proximity Read ↗

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.Semantic proximity Read ↗

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