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Article

A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.

The Journal of biological chemistry - 17 May 2002

Kanduri Chandrasekhar, Fitzpatrick Galina, Mukhopadhyay Rituparna, Kanduri Meena, Lobanenkov Victor, Higgins Michael, Ohlsson Rolf

Abstract excerpt

The mechanisms underlying the phenomenon of genomic imprinting remain poorly understood. In one instance, a differentially methylated imprinting control region (ICR) at the H19 locus has been shown to involve a methylation-sensitive chromatin insulator function that apparently partitions the neighboring Igf2 and H19 genes in different expression domains in a parent of origin-dependent manner. It is not known,...

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Identifiers

PMID: 11877438
DOI: 10.1074/jbc.M200031200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.PMID 11877438Read ↗

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Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

The number of the CTCF binding sites of the H19/IGF2:IG-DMR correlates with DNA methylation and expression imprinting in a humanized mouse modelSemantic proximity Read ↗

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