Article
The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.
Nucleic acids research - 19 Sept 2016
Termanis Ausma, Torrea Natalia, Culley Jayne, Kerr Alastair, Ramsahoye Bernard, Stancheva Irina
Abstract excerpt
Methylation of DNA at carbon 5 of cytosine is essential for mammalian development and implicated in transcriptional repression of genes and transposons. New patterns of DNA methylation characteristic of lineage-committed cells are established at the exit from pluripotency by de novo DNA methyltransferases enzymes, DNMT3A and DNMT3B, which are regulated by developmental signaling and require access to...
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