Article
Autonomous silencing of the imprinted Cdkn1c gene in stem cells.
Epigenetics - 1 Apr 2010
Wood Michelle D, Hiura Hitoshi, Tunster Simon J, Arima Takahiro, Shin Jong-Yeon, Higgins Michael J, John Rosalind M
Abstract excerpt
Parent-of-origin specific expression of imprinted genes relies on the differential DNA methylation of specific genomic regions. Differentially methylated regions (DMRs) acquire DNA methylation either during gametogenesis (primary DMR) or after fertilisation when allele-specific expression is established (secondary DMR). Little is known about the function of these secondary DMRs. We investigated the DMR spanning...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
