Article
ZFP57 dictates allelic expression switch of target imprinted genes.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2021
Jiang Weijun, Shi Jiajia, Zhao Jingjie, Wang Qiu, Cong Dan, Chen Fenghua, Zhang Yu, Liu Yuhan, Zhao Junzheng, Chen Qian, Gu Linhao, Zhou Wenjia, Wang Chenhang, Fang Zhaoyuan, Geng Shuhui, Xie Wei, Chen Luo-Nan, Yang Yang, Bai Yun, Lin Haodong, Li Xiajun
Abstract excerpt
ZFP57 is a master regulator of genomic imprinting. It has both maternal and zygotic functions that are partially redundant in maintaining DNA methylation at some imprinting control regions (ICRs). In this study, we found that DNA methylation was lost at most known ICRs in Zfp57 mutant embryos. Furthermore, loss of ZFP57 caused loss of parent-of-origin-dependent monoallelic expression of the target imprinted...
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