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Article

Lsh, a member of the SNF2 family, is required for genome-wide methylation.

Genes & development - 15 Nov 2001

Dennis K, Fan T, Geiman T, Yan Q, Muegge K

Abstract excerpt

Methylation patterns of the mammalian genome are thought to be crucial for development. The precise mechanisms designating specific genomic loci for methylation are not known. Targeted deletion of Lsh results in perinatal lethality with a rather normal development. We report here, however, that Lsh(-/-) mice show substantial loss of methylation throughout the genome. The hypomethylated loci comprise repetitive...

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Identifiers

PMID: 11711429
DOI: 10.1101/gad.929101
PMCID: PMC312825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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