Article
Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.
Genome research - 1 Dec 2002
Yatsuki Hitomi, Joh Keiichiro, Higashimoto Ken, Soejima Hidenobu, Arai Yuji, Wang Youdong, Hatada Izuho, Obata Yayoi, Morisaki Hiroko, Zhang Zhongming, Nakagawachi Tetsuji, Satoh Yuji, Mukai Tsunehiro
Abstract excerpt
Mouse chromosome 7F4/F5, where the imprinting domain is located, is syntenic to human 11p15.5, the locus for Beckwith-Wiedemann syndrome. The domain is thought to consist of the two subdomains Kip2 (p57(kip2))/Lit1 and Igf2/H19. Because DNA methylation is believed to be a key factor in genomic im...
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