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Article

Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.

Developmental cell - 1 Oct 2004

Kreuger Johan, Perez Lidia, Giraldez Antonio J, Cohen Stephen M

Abstract excerpt

The glypican family of heparan sulfate proteoglycans has been implicated in formation of morphogen gradients. Here, we examine the role of the glypican Dally-like protein (Dlp) in shaping the Wingless gradient in the Drosophila wing disc. Surprisingly, we find that Dlp has opposite effects at hig...

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Identifiers

PMID: 15469839
DOI: 10.1016/j.devcel.2004.08.005

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15469839-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.PMID 15469839Read ↗

HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.Semantic proximity Read ↗

Glypicans shunt the Wingless signal between local signalling and further transport.Semantic proximity Read ↗

Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc.Semantic proximity Read ↗

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila.Semantic proximity Read ↗

Lipoprotein-heparan sulfate interactions in the Hh pathway.Semantic proximity Read ↗

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.Semantic proximity Read ↗

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling.Semantic proximity Read ↗

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.Semantic proximity Read ↗

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.Semantic proximity Read ↗

Regulation of dally, an integral membrane proteoglycan, and its function during adult sensory organ formation of Drosophila.Semantic proximity Read ↗

The feedback regulator Nord controls Dpp/BMP signaling via extracellular interaction with Dally in the <i>Drosophila</i> wingSemantic proximity Read ↗

Fine-tuning of cell signaling by glypicans.Semantic proximity Read ↗

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