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Article

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011

Callejo Ainhoa, Bilioni Aphrodite, Mollica Emanuela, Gorfinkiel Nicole, Andrés Germán, Ibáñez Carmen, Torroja Carlos, Doglio Laura, Sierra Javier, Guerrero Isabel

Abstract excerpt

Hedgehog (Hh) moves from the producing cells to regulate the growth and development of distant cells in a variety of tissues. Here, we have investigated the mechanism of Hh release from the producing cells to form a morphogenetic gradient in the Drosophila wing imaginal disk epithelium. We describe that Hh reaches both apical and basolateral plasma membranes, but the apical Hh is subsequently internalized in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21690386
DOI: 10.1073/pnas.1106881108
PMCID: PMC3150953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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