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Article

A regulatory receptor network directs the range and output of the Wingless signal.

Development (Cambridge, England) - 1 Jun 2014

Schilling Sabine, Steiner Sarah, Zimmerli Dario, Basler Konrad

Abstract excerpt

The potent activity of Wnt/Wingless (Wg) signals necessitates sophisticated mechanisms that spatially and temporally regulate their distribution and range of action. The two main receptor components for Wg - Arrow (Arr) and Frizzled 2 (Fz2) - are transcriptionally downregulated by Wg signaling, thus forming gradients that oppose that of Wg. Here, we analyze the relevance of this transcriptional regulation for the...

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Identifiers

PMID: 24917503
DOI: 10.1242/dev.108662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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