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Article

WldS mice are resistant to paclitaxel (taxol) neuropathy.

Annals of neurology - 1 Oct 2002

Wang Min Sheng, Davis Albert A, Culver Deborah G, Glass Jonathan D

Abstract excerpt

The WldS mouse is a unique mutant strain that demonstrates the remarkable phenotype of prolonged survival of transected axons ("slow Wallerian degeneration"). In these studies, we tested whether this neuroprotective phenotype extends to axonal degeneration seen in a progressive peripheral neuropathy. WldS and wild-type mice were intoxicated with the cancer chemotherapeutic agent paclitaxel (Taxol). The severity...

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Share to Antineoplastic Agents, Phytogenic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12325073
DOI: 10.1002/ana.10300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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WldS mice are resistant to paclitaxel (taxol) neuropathy.PMID 12325073Read ↗

The WldS protein protects against axonal degeneration: a model of gene therapy for peripheral neuropathy.Semantic proximity Read ↗

The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine NeuropathySemantic proximity Read ↗

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.Semantic proximity Read ↗

Axonal involvement in the Wlds neuroprotective effect: analysis of pure motoneurons in a mouse model protected from motor neuron disease at a pre-symptomatic age.Semantic proximity Read ↗

Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.Semantic proximity Read ↗

Tau-mediated axonal degeneration is prevented by activation of the Wld <sup>S</sup> pathwaySemantic proximity Read ↗

A Chemotherapy-Induced Peripheral Neuropathy Model in Drosophila melanogaster.Semantic proximity Read ↗

WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.Semantic proximity Read ↗

Genotyping methods to detect a unique neuroprotective factor (Wld(s)) for axons.Semantic proximity Read ↗

Motor neuron death induced by axotomy in neonatal mice occurs more slowly in a mutant strain in which Wallerian degeneration is very slow.Semantic proximity Read ↗

Integrins protect nociceptive neurons in models of paclitaxel-mediated peripheral sensory neuropathySemantic proximity Read ↗

Mutations in a P-type ATPase gene cause axonal degeneration.Semantic proximity Read ↗

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