Article
Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.
Autophagy - 1 Jan 2018
Yamaguchi Junji, Suzuki Chigure, Nanao Tomohisa, Kakuta Soichirou, Ozawa Kentarou, Tanida Isei, Saitoh Tatsuya, Sunabori Takehiko, Komatsu Masaaki, Tanaka Keiji, Aoki Shigeki, Sakimura Kenji, Uchiyama Yasuo
Abstract excerpt
Conditional knockout mice for Atg9a, specifically in brain tissue, were generated to understand the roles of ATG9A in the neural tissue cells. The mice were born normally, but half of them died within one wk, and none lived beyond 4 wk of age. SQSTM1/p62 and NBR1, receptor proteins for selective autophagy, together with ubiquitin, accumulated in Atg9a-deficient neurosoma at postnatal d 15 (P15), indicating an...
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