Article
Nonparametric tests of association of multiple genes with human disease.
American journal of human genetics - 1 May 2005
Schaid Daniel J, McDonnell Shannon K, Hebbring Scott J, Cunningham Julie M, Thibodeau Stephen N
Abstract excerpt
The genetic basis of many common human diseases is expected to be highly heterogeneous, with multiple causative loci and multiple alleles at some of the causative loci. Analyzing the association of disease with one genetic marker at a time can have weak power, because of relatively small genetic effects and the need to correct for multiple testing. Testing the simultaneous effects of multiple markers by...
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