Article
Analysis of multiple SNPs in a candidate gene or region.
Genetic epidemiology - 1 Sept 2008
Chapman Juliet, Whittaker John
Abstract excerpt
We consider the analysis of multiple single nucleotide polymorphisms (SNPs) within a gene or region. The simplest analysis of such data is based on a series of single SNP hypothesis tests, followed by correction for multiple testing, but it is intuitively plausible that a joint analysis of the SNPs will have higher power, particularly when the causal locus may not have been observed. However, standard tests, such...
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