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Article

Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants.

PloS one - 1 Jan 2013

Petersen Ashley, Alvarez Carolina, DeClaire Scott, Tintle Nathan L

Abstract excerpt

Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative to single-marker tests. In this analysis we conduct a variety of simulation studies applied to five popular gene-based tests investigating general trends related to their performance in realistic situations. In particular, we focus on the impact of non-causal SNPs and a variety of LD structures on the behavior of...

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Identifiers

PMID: 23741293
DOI: 10.1371/journal.pone.0062161
PMCID: PMC3669368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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