Article
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes.
The Journal of allergy and clinical immunology - 1 Jan 2005
Pykäläinen Maritta, Kinos Riikka, Valkonen Sanna, Rydman Pia, Kilpeläinen Maritta, Laitinen Lauri A, Karjalainen Jussi, Nieminen Markku, Hurme Mikko, Kere Juha, Laitinen Tarja, Lahesmaa Riitta
Abstract excerpt
BACKGROUND: Immune responses characterized by T H 2 type cells and IgE are important for the development of asthma and atopy. The transcription factors STAT6, GATA3, and STAT4 mediate the cytokine-induced development of naive CD4 + T cells into either T H 1 or T H 2 type. OBJECTIVE: We studied genetic variation of the STAT6, GATA3, and STAT4 genes and examined whether single nucleotide polymorphisms (SNPs) in...
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