Article
Novel dinucleotide repeat polymorphism in the first exon of the STAT-6 gene is associated with allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Oct 2001
Tamura K, Arakawa H, Suzuki M, Kobayashi Y, Mochizuki H, Kato M, Tokuyama K, Morikawa A
Abstract excerpt
BACKGROUND: T helper-type 2 cytokines, such as interleukin-4 (IL-4) and IL-13, may play a central role in allergic diseases. The protein known as 'signal transducers and activators of transcription 6' (STAT-6) is a key transcription factor involved in both IL-4- and IL-13-mediated biological responses. OBJECTIVE: The objective of this study was to evaluate the possible role of the STAT-6 gene in modulating atopy...
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