Article
Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast.
Molecular and cellular biology - 1 Jan 2005
Fagerström-Billai Fredrik, Wright Anthony P H
Abstract excerpt
Gene duplication is considered an important evolutionary mechanism. Unlike many characterized species, the fission yeast Schizosaccharomyces pombe contains two paralogous genes, tup11+ and tup12+, that encode transcriptional corepressors similar to the well-characterized budding yeast Tup1 protein. Previous reports have suggested that Tup11 and Tup12 proteins play redundant roles. Consistently, we show that the...
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