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Article

Genome-wide analysis of the functions of a conserved surface on the corepressor Tup1.

Molecular biology of the cell - 1 Jun 2005

Green Sarah R, Johnson Alexander D

Abstract excerpt

The general transcriptional repressor Tup1 is responsible for the regulation of a large, diverse set of genes in Saccharomyces cerevisiae, and functional homologues of Tup1 have been identified in many metazoans. The crystal structure for the C-terminal portion of Tup1 has been solved and, when sequences of Tup1 homologues from fungi and metazoans were compared, a highly conserved surface was revealed. In this...

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Identifiers

PMID: 15788561
DOI: 10.1091/mbc.e05-02-0126
PMCID: PMC1142409

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