Article
Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog.
Molecular and cellular biology - 1 Dec 1999
Mukai Y, Matsuo E, Roth S Y, Harashima S
Abstract excerpt
The Ssn6p-Tup1p corepressor complex is important to the regulation of several diverse genes in Saccharomyces cerevisiae and serves as a model for corepressor functions. To investigate the evolutionary conservation of these functions, sequences homologous to the S. cerevisiae TUP1 gene were cloned from Kluyveromyces lactis (TUP1) and Schizosaccharomyces pombe (tup11(+)). Interestingly, while the K. lactis TUP1...
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