Article
Transcriptional repression by Kluyveromyces lactis Tup1 in Saccharomyces cerevisiae.
Journal of industrial microbiology & biotechnology - 1 Jan 2011
Lamas-Maceiras Mónica, Freire-Picos María Angeles, Torres Ana Maria Rodríguez
Abstract excerpt
The general repression complex, constituted by the yeast Tup1 and Ssn6 factors, is a conserved global regulator of transcription in eukaryotes. In the yeast Saccharomyces cerevisiae, it is an important repressor of hypoxic genes, such as ANB1, under aerobic conditions and deletion of the TUP1 gene causes a flocculation phenotype. The KlTUP1 gene from the yeast Kluyveromyces lactis encodes for a protein with 83%...
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