Article
Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.
Molecular biology of the cell - 1 Jun 2005
García-Sánchez Susana, Mavor Abigail L, Russell Claire L, Argimon Silvia, Dennison Paul, Enjalbert Brice, Brown Alistair J P
Abstract excerpt
In budding yeast, Tup1 and Ssn6/Cyc8 form a corepressor that regulates a large number of genes. This Tup1-Ssn6 corepressor appears to be conserved from yeast to man. In the pathogenic fungus Candida albicans, Tup1 regulates cellular morphogenesis, phenotypic switching, and metabolism, but the role of Ssn6 remains unclear. We show that there are clear differences in the morphological and invasive phenotypes of C....
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