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Article

Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.

The EMBO journal - 15 Jun 2000

Sprague E R, Redd M J, Johnson A D, Wolberger C

Abstract excerpt

The Tup1-Ssn6 corepressor complex regulates the expression of several sets of genes, including genes that specify mating type in the yeast Saccharomyces cerevisiae. Repression of mating-type genes occurs when Tup1-Ssn6 is brought to the DNA by the Matalpha2 DNA-binding protein and assembled upstream of a- and haploid-specific genes. We have determined the 2.3 A X-ray crystal structure of the C-terminal domain of...

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Identifiers

PMID: 10856245
DOI: 10.1093/emboj/19.12.3016
PMCID: PMC203344

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