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Article

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation.

The Journal of cell biology - 3 Jan 2005

Cheng Zhiliang, Jiang Ying, Mandon Elisabet C, Gilmore Reid

Abstract excerpt

The cytoplasmic surface of Sec61p is the binding site for the ribosome and has been proposed to interact with the signal recognition particle receptor during targeting of the ribosome nascent chain complex to the translocation channel. Point mutations in cytoplasmic loops six (L6) and eight (L8) of yeast Sec61p cause reductions in growth rates and defects in the translocation of nascent polypeptides that use the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15631991
DOI: 10.1083/jcb.200408188
PMCID: PMC2171681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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