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Article

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.

The Journal of cell biology - 24 Mar 2008

Jiang Ying, Cheng Zhiliang, Mandon Elisabet C, Gilmore Reid

Abstract excerpt

The signal recognition particle (SRP)-dependent targeting pathway facilitates rapid, efficient delivery of the ribosome-nascent chain complex (RNC) to the protein translocation channel. We test whether the SRP receptor (SR) locates a vacant protein translocation channel by interacting with the yeast Sec61 and Ssh1 translocons. Surprisingly, the slow growth and cotranslational translocation defects caused by...

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Source

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Identifiers

PMID: 18347066
DOI: 10.1083/jcb.200707196
PMCID: PMC2290843

Genes

SSH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.PMID 18347066Read ↗

Ssh1p determines the translocation and dislocation capacities of the yeast endoplasmic reticulum.Semantic proximity Read ↗

The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.Semantic proximity Read ↗

Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids.Semantic proximity Read ↗

Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.Semantic proximity Read ↗

A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation.Semantic proximity Read ↗

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.Semantic proximity Read ↗

The signal recognition particle in S. cerevisiae.Semantic proximity Read ↗

The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.Semantic proximity Read ↗

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