Article
Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster.
Archives of general psychiatry - 1 Jan 2005
Radel Marta, Vallejo Roger L, Iwata Nakao, Aragon Richard, Long Jeffrey C, Virkkunen Matti, Goldman David
Abstract excerpt
CONTEXT: Pharmacobehavioral and pharmacogenetic evidence links gamma-aminobutyric acid type A (GABA(A)) receptors and chromosomal regions containing GABA(A) receptor genes to ethanol-related responses. The GABA(A) gene cluster on chromosome 5q34 is of particular interest in the genetics of alcohol dependence because of the gamma2 subunit requirement for ethanol's modulatory action on GABA(A) receptors, previous...
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