Article
Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4.
Genomics - 1 Jan 2008
Ittiwut Chupong, Listman Jennifer, Mutirangura Apiwat, Malison Robert, Covault Jonathan, Kranzler Henry R, Sughondhabirom Atapol, Thavichachart Nuntika, Gelernter Joel
Abstract excerpt
GABRA2 and GABRG1, which encode the alpha-2 and gamma-1 subunits, respectively, of the GABA(A) receptor, are located in a cluster on chromosome 4p. The GABRA2 locus has been found to be associated with alcohol dependence in several studies, but no functional variant that can account for this association has been identified. To understand the reported associations, we sought to understand the linkage...
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