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Article

The mutagenic potential of duodenoesophageal reflux.

Annals of surgery - 1 Jan 2005

Theisen Jörg, Peters Jeffrey H, Fein Martin, Hughes Michael, Hagen Jeffrey A, Demeester Steven R, Demeester Tom R, Laird Peter W

Abstract excerpt

SUMMARY BACKGROUND DATA: Duodenogastric-esophageal reflux disease is directly linked to Barrett's esophagus and to the development of esophageal adenocarcinoma. Despite this link, little is known about the mutagenic potential of refluxed material on the esophageal mucosa. We hypothesize that the reflux of gastric and duodenal content causes mutations in esophageal mucosa in vivo. METHODS: Seven Sprague Dawley/Big...

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Identifiers

PMID: 15621992
DOI: 10.1097/01.sla.0000150072.55037.e3
PMCID: PMC1356847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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