Article
Molecular analysis of lacI mutants from transgenic fibroblasts exposed to 1,2-epoxybutene.
Carcinogenesis - 1 Nov 1998
Saranko C J, Pluta L J, Recio L
Abstract excerpt
1,3-Butadiene (BD) is a genotoxic carcinogen that is bioactivated to at least two mutagenic metabolites: 1,2-epoxybutene (EB) and 1,2:3,4-diepoxybutane (DEB). We reported previously that lacI transgenic mice exposed to BD had an increased frequency of specific base substitution mutations in the b...
Topics
- Animals
- Bacterial Proteins
- Epoxy Compounds
- Escherichia coli Proteins
- Fibroblasts
- Lac Repressors
- Mice
- Mutagens
- Mutation
- Rats
- Repressor Proteins
- Transfection