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Article

Carcinogenesis in reflux disease--in search for bile-specific effects.

Microsurgery - 1 Jan 2007

Fein Martin, Peters Jeffrey H, DeMeester Tom R

Abstract excerpt

Bile reflux may play a key role for esophageal carcinogenesis in reflux disease. In search for bile-specific effects, the animal model of esophageal cancer was applied in a mutagenesis assay. Big Blue transgenic mice were operated with microsurgical techniques. Seven had total gastrectomy with esophagojejunostomy creating esophageal reflux of bile and five had a sham operation. After 24 weeks, the mutation...

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Identifiers

PMID: 17929260
DOI: 10.1002/micr.20424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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