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Article

Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000

Aoki Yasunobu, Taniguchi Yosuke, Matsumoto Michiyo, Matsumoto Michi, Ohno Mizuki, Masumura Kenichi, Sasaki Shigeki, Tsuzuki Teruhisa, Yamamoto Masayuki, Nohmi Takehiko

Abstract excerpt

Tumorigenesis induced by oxidative stress is thought to be initiated by mutagenesis, but via an indirect mechanism. The dose-response curves for agents that act by this route usually show a threshold, for unknown reasons. To gain insight into these phenomena, we have analyzed the dose response for mutagenesis induced by the oral administration of potassium bromate, a typical oxidative-stress-generating agent, to...

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Identifiers

PMID: 32247553
DOI: 10.1016/j.mrgentox.2020.503136

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