Article
Mutations induced by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in cecum and proximal and distal colon of lacI transgenic rats.
Mutagenesis - 1 Sept 2001
Stuart G R, de Boer J G, Haesevoets R, Holcroft J, Kangas J, Sojonky K, Thorleifson E, Thornton A, Walsh D F, Yang H, Glickman B W
Abstract excerpt
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-borne mutagen and carcinogen that induces tumors of the colon and the prostate gland in male rats and of the mammary gland in female rats. In this study we describe the frequency and specificity of PhIP-induced mutations in the cecum, proximal colon and distal colon of male and female lacI transgenic rats. This is the first report of mutational data...
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