Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene.

doi:10.1016/s1383-5718(97)00146-0

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Article

Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene.

Mutation research - 12 Dec 1997

Okonogi H, Stuart G R, Okochi E, Ushijima T, Sugimura T, Glickman B W, Nagao M

Abstract excerpt

Feeding of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to F344 rats induces colon tumors specifically in male rats. Mutant frequencies and mutational spectra of the lacI transgene were studied in male and female Big Blue transgenic rats after feeding 400 ppm of PhIP in the diet for 60...

Topics

Animals
Animals, Genetically Modified
Bacterial Proteins
Carcinogens
Escherichia coli Proteins
Female
Imidazoles
Intestinal Mucosa
Lac Repressors
Male
Mice
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Rats, Inbred F344

Repressor Proteins

Sex Factors

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 9465918
DOI: 10.1016/s1383-5718(97)00146-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9465918-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene.PMID 9465918Read ↗

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