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Article

Activation of tyrosine kinase of EGFR induces Gbetagamma-dependent GRK-EGFR complex formation.

FEBS letters - 3 Jan 2005

Gao Jingxia, Li Jiali, Chen Yuejun, Ma Lan

Abstract excerpt

This study demonstrated that activation of tyrosine kinase of epidermal growth factor receptor (EGFR) induces its association with G protein-coupled receptor kinase 2 (GRK2). Immunoprecipitation experiments showed that EGF stimulation increased GRK2 binding to EGFR complex in HEK293 cells coexpressing EGFR and GRK2. The EGF-induced GRK2-EGFR complex formation was greatly reduced by perturbation of EGFR and Src...

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Share to Cyclic AMP-Dependent Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15620700
DOI: 10.1016/j.febslet.2004.11.057

Genes

EGFR
GRK2
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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