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Article

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.

The EMBO journal - 1 Feb 2002

Waterman Hadassa, Katz Menachem, Rubin Chanan, Shtiegman Keren, Lavi Sara, Elson Ari, Jovin Thomas, Yarden Yosef

Abstract excerpt

Ligand-induced desensitization of the epidermal growth factor receptor (EGFR) is controlled by c-Cbl, a ubiquitin ligase that binds multiple signaling proteins, including the Grb2 adaptor. Consistent with a negative role for c-Cbl, here we report that defective Tyr1045 of EGFR, an inducible c-Cbl docking site, enhances the mitogenic response to EGF. Signaling potentiation is due to accelerated recycling of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11823423
DOI: 10.1093/emboj/21.3.303
PMCID: PMC125825

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.PMID 11823423Read ↗

A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.Semantic proximity Read ↗

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.Semantic proximity Read ↗

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.Semantic proximity Read ↗

Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptorsSemantic proximity Read ↗

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.Semantic proximity Read ↗

Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.Semantic proximity Read ↗

Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.Semantic proximity Read ↗

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies.Semantic proximity Read ↗

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.Semantic proximity Read ↗

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.Semantic proximity Read ↗

[Ubiquitination-mediated degradation of epidermal growth factor receptor].Semantic proximity Read ↗

The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor.Semantic proximity Read ↗

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