Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characteristics of EGFR family-mediated HRG signals in human ovarian cancer

15 Jun 1999

Abstract excerpt

The ability of the epidermal growth factor receptor (EGFR) family members, EGFR, HER2, HER3, and HER4, to form homo- and heterodimers after interaction with different ligands expands the signal diversity of these proteins. We investigated their mechanism of activation by exogenous EGF and heregulin (HRG) in human ovarian carcinoma cell lines which express different amounts and combinations of the four receptors....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to HER2/EGFR in Cancer Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10733345
DOI: 10.1002/(sici)1097-4644(19990615)73:4<522::aid-jcb10>3.0.co;2-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characteristics of EGFR family-mediated HRG signals in human ovarian cancerPMID 10733345Read ↗

Human EGF receptor (HER) family and heregulin members are differentially expressed in epidermal keratinocytes and modulate differentiation.Semantic proximity Read ↗

Role of HER receptors family in development and differentiationSemantic proximity Read ↗

Epidermal growth factor receptor (EGFR) signaling in cancer.Semantic proximity Read ↗

HER2 Oncogenic Function Escapes EGFR Tyrosine Kinase Inhibitors via Activation of Alternative HER Receptors in Breast Cancer CellsSemantic proximity Read ↗

Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell linesSemantic proximity Read ↗

HER4 Mediates Ligand-Dependent Antiproliferative and Differentiation Responses in Human Breast Cancer CellsSemantic proximity Read ↗

Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB ReceptorsSemantic proximity Read ↗

Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines.Semantic proximity Read ↗

Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signalingSemantic proximity Read ↗

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cellsSemantic proximity Read ↗

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.Semantic proximity Read ↗

Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.