Article
Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors.
Cancer research - 15 Jul 2006
Yang Seungchan, Qu Shimian, Perez-Tores Marianela, Sawai Ayana, Rosen Neal, Solit David B, Arteaga Carlos L
Abstract excerpt
Activating mutations in the epidermal growth factor receptor (EGFR), localized in the activation loop within the kinase domain, have been discovered in non-small cell lung cancers (NSCLC). Most of these mutants are exquisitely sensitive to EGFR tyrosine kinase inhibitors, suggesting that they generate receptor dependence in the cancers that express them. 32D cells stably expressing EGFR-L861Q and EGFR-L858R but...
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