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Article

Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2.

The EMBO journal - 17 Sept 2001

Penela P, Elorza A, Sarnago S, Mayor F

Abstract excerpt

G-protein-coupled receptor kinase 2 (GRK2) plays a key role in the regulation of G-protein-coupled receptors (GPCRs). GRK2 expression is altered in several pathological conditions, but the molecular mechanisms that modulate GRK2 cellular levels are largely unknown. We recently have described that GRK2 is degraded rapidly by the proteasome pathway. This process is enhanced by GPCR stimulation and is severely...

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Identifiers

PMID: 11566877
DOI: 10.1093/emboj/20.18.5129
PMCID: PMC125273

Genes

GRK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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